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IP6 and cancer: what the evidence says

Animal studies and case reports suggest IP6 may act against several kinds of cancer, but no controlled human trial has measured its effect on tumors.

2/5 Preliminary

Animal studies, and at most single case reports in people. No controlled human trial on this outcome. How we score

A research summary, not a substitute for treatment. If you or someone you care for has cancer, talk to the oncologist before adding any supplement, and do not delay or replace treatment.

Most of the research is in cell cultures and animals: 213 lab papers and 113 animal papers in PubMed mention IP6 and cancer, and a 2002 systematic review found the animal studies mostly showed anti-cancer effects in breast, colon, liver, leukemia, prostate, sarcoma and skin cancer.

In people, the evidence is one case report: a patient with stage IV melanoma who declined standard treatment, took over-the-counter IP6 plus inositol, and was in complete remission three years later.

The two small human trials that exist measured chemotherapy side effects, not tumor response, so they are counted on the chemotherapy page instead.

The evidence ladder higher rungs count for more
  1. Meta-analyses of trialspooled randomized trials0
  2. Human studiestrials and population studies0
  3. Case reportssingle people1
  4. Animal studiesmostly rodents113
  5. Lab studiescells, test tubes213

The studies in people, read one by one

ResultTypeWhat they didWhat they found
PositiveCase report, 2019
1 people		Case report, stage IV melanoma, IP6 + inositol instead of standard treatment
Measured: Tumor response		Complete remission, still in remission three years later. A single case cannot show the supplement caused it. PubMed 30615010
PositiveSystematic review / meta-analysis, 2002Systematic review of 28 studies (Medline 1966–2002)
Measured: Anti-cancer effect		Mostly animal studies showing anti-cancer effects; no human studies existed; called for Phase I and II trials. PubMed 12594974
PositiveReview, 2025Narrative review by long-time IP6 researchers
Measured: Overall evidence		Concludes preclinical and limited clinical research is promising and that clinical trials remain limited. PubMed 41463308

Where the sources agree, and where they don’t

4 of 6 kinds of source point toward a benefit, 0 toward no effect or harm, 0 are mixed, and 2 have no data yet. Agreement between independent kinds of evidence matters more than the number of papers in any one of them.

Kind of sourcePoints toDetail
Lab and animal studiesPositive326 papers, mostly positive
Human trials on tumorsNo datanone exist
Case reportsPositive1 melanoma remission
PatentsPositive1990 tumor-inhibition patent (a claim)
Public reportsPositive17 of 28 say it helped, nearly all alongside standard treatment
FDA reportsNo datano cancer-specific reports; general safety reports listed above

Beyond Google: 5 findings about IP6 from trial registries, FDA reports and patent offices that a normal search rarely shows. See them

What people report

We read public first-person posts and counted every outcome, good or bad. 28 reports about this condition, read on 2026-10-27; 6 mention side effects.

  • 17Helped
  • 1No effect
  • 3Got worse
  • 4Mixed
  • 3Too early

Why these counts prove nothing on their own: people who post are not a random sample, most take other treatments at the same time, and nobody checks the diagnosis. We show them because they tell researchers what to test next.

Read all 28 reports
  • Helped After years of slowly rising PSA despite other treatments, PSA stopped rising and fell to a stable level within months of starting IP6+inositol. HealthUnlocked, 2022-07-27 (Prior Lupron and radiation history; PSA-only measure; poster says 'if this is helping me'.)
  • Helped Reports PSA dropping after six months of three scoops daily on an empty stomach. HealthUnlocked, 2024-01-30 (Small PSA values; in another thread the same poster reported a drop from 0.3 to 0.2 after three months; no follow-up given.)
  • Too early Thinks it may make a difference and feels better mentally, but says he does not know its effect on the cancer until his next PSA. HealthUnlocked, 2022-08 (Self-described uncertainty; no PSA result reported; exact reply date not shown.)
  • Helped PSA levelled off while taking IP6+inositol, but the poster says it could be IP6, metformin, MCP or coincidence. HealthUnlocked, 2022-08 (Concurrent metformin and MCP; poster explicitly cannot attribute; exact reply date not shown.)
  • Helped Caregiver reports husband's long-stable triglycerides fell from 154 to about 120 after three months of 8 g IP6 daily. HealthUnlocked, 2019-01 (Caregiver report; poster says she cannot prove IP6 caused it; single measurement.)
  • Mixed Took IP6 for a period; says the cancer eventually 'found a work-around' and PSA began rising again. HealthUnlocked, 2016-08 (Implies a temporary benefit without data; many supplements tried; date inferred from thread timestamps.)
  • Too early After three weeks at 12 g daily the PSA rise slowed sharply; plans to retest to see whether it was coincidence. Side effects: gas (first 7-10 days). Inspire, 2018-11-13 (Only three weeks; poster flags possible coincidence.)
  • Helped Reports a PSA drop to 0.1, no palpable prostate nodules and an end to bone ache after high-dose IP6; lower doses did not work. Side effects: gas, more frequent bathroom trips. Inspire, 2018-10-24 (On hormone therapy throughout; a prominent advocate who posts widely; elsewhere says he is slightly anemic without blaming IP6.)
  • Helped PSA fell from 55 to under 0.1 within months while taking nine scoops of IP6 daily alongside hormone therapy. Side effects: gas. Inspire, 2018-10-18 (Started hormone therapy at the same time, which alone usually lowers PSA sharply; cannot attribute.)
  • No effect PSA went from 0.52 to 0.564 after 23 days of 16 scoops of IP6 daily. Inspire, 2022-04-13 (Only 23 days; many concurrent supplements.)
  • Worse Gained 12 pounds in ten days on IP6 and stopped; says he does not know whether IP6 works. Side effects: weight gain. Inspire, 2019-05-05 (Very short use; on Lupron, which itself can cause weight gain.)
  • Too early PSA is down, but he is unsure IP6 played a role and says it is too early to tell. ExcelMale, 2019-03-28 (Irregular use; poster's own 'too early' statement.)
  • Helped Credits a high dose of IP6+inositol with reaching no evidence of disease; in 2016 reported three years in remission. Inspire, 2013-11-29 (Also had chemotherapy and radiation; strongly promotes a specific brand.)
  • Worse Mother became tired, weak and unable to eat within three weeks of starting IP6; she improved within days of stopping it. Side effects: fatigue, weakness, loss of appetite, nausea, difficulty swallowing. Inspire, 2013-01-11 (Caregiver report; grape seed extract taken too and iron supplement stopped; suspected iron deficiency not confirmed by a lab test.)
  • Helped Says taking 6-8 pills twice daily throughout Taxol chemotherapy prevented neuropathy for her. Inspire, 2011-12-02 (Not everyone on Taxol develops neuropathy; another poster in the same thread reports the opposite.)
  • Mixed IP6 did not prevent severe Taxol neuropathy, but she credits it with far fewer colds over four years. Inspire, 2011-12-03 (Benefit claim is about colds, a subjective and unrelated measure.)
  • Helped Had a complete pathologic response after chemotherapy while taking 6 g IP6+inositol daily, but stresses he cannot know whether it contributed. Inspire, 2010-01-02 (Standard chemotherapy and surgery; the poster himself disclaims attribution.)
  • Helped Platelets recovered to their highest level in months after adding IP6; a later scan showed a clear liver and shrinking lung tumors. Inspire, 2010-02-25 (On Tarceva and Gemzar; the poster says he is not sure which is working; in 2011 he reported stable cancer and no side effects.)
  • Helped A seven-year survivor taking two tablets daily since diagnosis believes it helps because she is still alive. Inspire, 2011-03-09 (Survival is not attributable; other treatment not stated.)
  • Worse Felt all-day pain where her tumors are after starting five pills twice daily; unsure whether it signals harm or a response. Side effects: pain at tumor sites, rib cage and lower back pain. Inspire, 2012-12-01 (Cause unknown; untreated cancer can cause pain; she made a similar post a day earlier.)
  • Helped Diagnosed in 2002; says she has been completely healed for ten years and still takes IP6+inositol. Inspire, 2012-12-01 (Other treatments not stated; strong advocacy tone.)
  • Mixed Rib pain from metastasis almost disappeared after four months on IP6, but her CEA tumor marker rose from 9.7 to 39.4. Inspire, 2010-06-02 (On Tarceva; she later reported coughing up blood; no scan result was posted.)
  • Helped Took six capsules at a time for a long period and says he felt better while on it. Inspire, 2018-10-08 (Subjective and vague; condition inferred from the community.)
  • Helped A six-year survivor says daily IP6 powder has kept her regular after decades of constipation, while allowing for placebo. Inspire, 2008-07-27 (Poster herself mentions a placebo effect; makes no cancer claim.)
  • Helped In remission for about eight years and believes her supplements, including IP6+inositol, have helped keep her there. Inspire, 2008-09-02 (Credits a supplement combination, not IP6 alone; had chemotherapy earlier.)
  • Helped Scans showed significant reduction and then stability, with no metastases, while taking IP6 and curcumin alongside chemotherapy and radiation. Inspire, 2010-09-16 (Standard chemotherapy and radiation at the same time; the poster does not directly credit IP6.)
  • Helped Takes 12 tablets twice daily and says she is alive three years past her expected death, crediting IP6+inositol. Inspire, 2016-02-20 (Cancer type and treatments not stated; strong advocacy tone.)
  • Mixed Two months at 10 g daily had no effect on the BCR-ABL leukemia marker, but cholesterol improved significantly. CML Support (UK), 2024-03-29 (Short trial; cholesterol change unexplained.)

Every other paper we found

PubMed returned 445 papers for this search on 2026-10-27. We read the human studies above ourselves. The rest are sorted by type automatically from PubMed's labels, which are sometimes wrong. We removed 15 papers that only mention the words, such as radioactive "phytate" tracers used in surgery.

Animal studies 113
  1. The Combination of Phytic Acid and Inositol Alleviates Metastasis of Colorectal Cancer in Mice by Inhibiting PI3K/AKT Pathway and M2 Macrophage Polarization. Biol Pharm Bull, 2025
  2. A novel mucoadhesive phytic acid grafted chitosan nanocarrier encapsulated with cisplatin for site-specific cervical cancer therapy: in vitro and in vivo assessments. J Drug Target, 2025
  3. Dual-radionuclide in vivo imaging of micro-metastasis and lymph tract with submillimetre resolution. Sci Rep, 2023
  4. Dietary phytate induces subclinical mechanical allodynia in mice. Braz J Med Biol Res, 2023
  5. Colon targeted releases and uptakes of paclitaxel loaded in modified porous starch. Carbohydr Polym, 2023
  6. Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model. Nutr Cancer, 2021
  7. Decreasing undesirable absorbed radiation to the intestine after administration of radium-223 dichloride for treatment of bone metastases. Sci Rep, 2020
  8. Dietary phytic acid weakened the antimicrobial activity and aggravated the inflammatory status of head kidney, spleen and skin in on-growing grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol, 2020
  9. Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/β-Catenin Pathway. Onco Targets Ther, 2020
  10. Development and characterization of pellets for targeted delivery of 5-fluorouracil and phytic acid for treatment of colon cancer in Wistar rat. Heliyon, 2020
  11. The Acute Effects of Oral Administration of Phytic Acid-Chitosan-Magnetic Iron Oxide Nanoparticles in Mice. Int J Mol Sci, 2019
  12. Phytic acid disrupted intestinal immune status and suppressed growth performance in on-growing grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol, 2019
  13. PI3K/Akt Pathway and miR-21 are Involved in N-Ethyl-N-Nitrosourea-Induced F1 Mouse Lung Tumorigenesis: Effect of Inositol Hexaphosphate. J Environ Pathol Toxicol Oncol, 2019
  14. Pectin-encrusted gold nanocomposites containing phytic acid and jacalin: 1,2-dimethylhydrazine-induced colon carcinogenesis in Wistar rats, PI3K/Akt, COX-2, and serum metabolomics as potential targets. Drug Deliv Transl Res, 2019
  15. Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. Br J Nutr, 2018
  16. Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3β/β-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model. Eur J Pharmacol, 2017
  17. Colloidal Vesicular System of Inositol Hexaphosphate to Counteract DMBA Induced Dysregulation of Markers Pertaining to Cellular Proliferation/Differentiation and Inflammation of Epidermal Layer in Mouse Model. Mol Pharm, 2017
  18. Inositol hexa phosphoric acid (phytic acid), a nutraceuticals, attenuates iron-induced oxidative stress and alleviates liver injury in iron overloaded mice. Biomed Pharmacother, 2017
  19. Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice. Nutrients, 2016
  20. Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. Cell Signal, 2016
  21. Dietary phytic acid modulates characteristics of the colonic luminal environment and reduces serum levels of proinflammatory cytokines in rats fed a high-fat diet. Nutr Res, 2014
  22. Involvement of EZH2, SUV39H1, G9a and associated molecules in pathogenesis of urethane induced mouse lung tumors: potential targets for cancer control. Toxicol Appl Pharmacol, 2014
  23. Involvement of epigenetics and microRNA-29b in the urethane induced inception and establishment of mouse lung tumors. Exp Mol Pathol, 2014
  24. Anti-VEGFR agents ameliorate hepatic venous dysregulation/microcirculatory dysfunction, splanchnic venous pooling and ascites of NASH-cirrhotic rat. Liver Int, 2014
  25. Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways. Biomed Res Int, 2013
  26. Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA). Asian Pac J Cancer Prev, 2013
  27. Inositol phosphates compete with nucleic acids for binding to bovine leukemia virus matrix protein: implications for deltaretroviral assembly. Proteins, 2013
  28. A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity. PLoS One, 2013
  29. Inositol hexaphosphate inhibits tumor growth, vascularity, and metabolism in TRAMP mice: a multiparametric magnetic resonance study. Cancer Prev Res (Phila), 2013
  30. Involvement of STAT3, NF-κB and associated downstream molecules before and after the onset of urethane induced lung tumors in mouse. Environ Toxicol Pharmacol, 2012
  31. Dietary rice bran component γ-oryzanol inhibits tumor growth in tumor-bearing mice. Mol Nutr Food Res, 2012
  32. Sulfosalicylate mediates improved vinorelbine loading into LUVs and antineoplastic effects. J Liposome Res, 2012
  33. Protective effect of inositol hexaphosphate against UVB damage in HaCaT cells and skin carcinogenesis in SKH1 hairless mice. Comp Med, 2011
  34. Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. J Med Food, 2011
  35. Pharmacokinetics and tissue distribution of inositol hexaphosphate in C.B17 SCID mice bearing human breast cancer xenografts. Metabolism, 2011
  36. Epigenetics, an early event in the modulation of gene expression by inositol hexaphosphate in ethylnitrosourea exposed mouse lungs. Nutr Cancer, 2011
  37. Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats. Exp Toxicol Pathol, 2010
  38. Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target. Cancer Res, 2009
  39. Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Oncogene, 2009
  40. Effect of inositol hexaphosphate on the development of UVB-induced skin tumors in SKH1 hairless mice. Comp Med, 2009
  41. Inositol hexaphosphate induces apoptosis by coordinative modulation of P53, Bcl-2 and sequential activation of caspases in 7,12 dimethylbenz[a]anthracene exposed mouse epidermis. J Environ Pathol Toxicol Oncol, 2008
  42. Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice. Clin Cancer Res, 2008
  43. Apoptotic effects of inositol hexaphosphate on biomarker Itpr3 in induced colon rat carcinogenesis. Acta Cir Bras, 2008
  44. Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats. Acta Cir Bras, 2006
  45. Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice. Acta Cir Bras, 2006
  46. Inositol hexaphosphate represses telomerase activity and translocates TERT from the nucleus in mouse and human prostate cancer cells via the deactivation of Akt and PKCalpha. Biochem Biophys Res Commun, 2006
  47. The biochemical changes associated with phytic Acid on induced breast proliferative lesions in rats: preliminary findings. Cancer Biol Ther, 2006
  48. Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats. World J Gastroenterol, 2005
  49. Study of the absorption of myo-inositol hexakisphosphate (InsP6) through the skin. Biol Pharm Bull, 2005
  50. Dietary administration of inositol and/or inositol-6-phosphate prevents chemically-induced rat hepatocarcinogenesis. Asian Pac J Cancer Prev, 2005
  51. Absorption of myo-inositol hexakisphosphate (InsP6) through the skin: study of the matrix effects. mechanism of phytate topical absorption. Front Biosci, 2005
  52. Effects of iron and phytic acid on production of extracellular radicals by Enterococcus faecalis. Exp Biol Med (Maywood), 2004
  53. In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. Clin Cancer Res, 2004
  54. Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells. Int J Oncol, 2003
  55. Suppression of DMBA-induced mouse skin tumor development by inositol hexaphosphate and its mode of action. Nutr Cancer, 2003
  56. Lignan precursors from flaxseed or rye bran do not protect against the development of intestinal neoplasia in ApcMin mice. Nutr Cancer, 2003
  57. Purified and endogenous phytic acid in wheat bran affects early biomarkers of colon cancer risk. IARC Sci Publ, 2002
  58. Genotoxicity of iron chelators in L5178Y mouse lymphoma cells. Environ Mol Mutagen, 2001
  59. Pilot study of a specific dietary supplement in tumor-bearing mice and in stage IIIB and IV non-small cell lung cancer patients. Nutr Cancer, 2001
  60. Inositol hexaphosphate inhibits ultraviolet B-induced signal transduction. Mol Carcinog, 2001
  61. Phytic acid in wheat bran affects colon morphology, cell differentiation and apoptosis. Carcinogenesis, 2000
  62. The effects of inositol hexaphosphate on the inflammatory response in transformed RAW 264.7 macrophages. Biomed Sci Instrum, 2000
  63. Inhibition of skin cancer by IP6 in vivo: initiation-promotion model. Anticancer Res, 1999
  64. Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis. Anticancer Res, 1999
  65. Dietary intrinsic phytate protects colon from lipid peroxidation in pigs with a moderately high dietary iron intake. Proc Soc Exp Biol Med, 1999
  66. IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice. Anticancer Res, 1998
  67. Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo. Anticancer Res, 1998
  68. The influence of phytic acid in wheat bran on early biomarkers of colon carcinogenesis. Carcinogenesis, 1998
  69. Protective effects of cruciferous seed meals and hulls against colon cancer in mice. Cancer Lett, 1998
  70. Increases in the concentrations of available iron in response to dietary iron supplementation are associated with changes in crypt cell proliferation in rat large intestine. J Nutr, 1998
  71. Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea. Carcinogenesis, 1997
  72. Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase. Cancer Res, 1997
  73. Inositol hexakisphosphate stimulates non-Ca2+-mediated and primes Ca2+-mediated exocytosis of insulin by activation of protein kinase C. Proc Natl Acad Sci U S A, 1997
  74. Colon tumor promotion: is it a selective process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts. Cancer Lett, 1997
  75. Effects of n-tritriacontane-16,18-dione, curcumin, chlorphyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model. Cancer Lett, 1997
  76. Comparison of pure inositol hexaphosphate and high-bran diet in the prevention of DMBA-induced rat mammary carcinogenesis. Nutr Cancer, 1997
  77. The effect of casein phosphopeptides on zinc and calcium absorption from high phytate infant diets assessed in rat pups and Caco-2 cells. Pediatr Res, 1996
  78. A rapid dual organ rat carcinogenesis bioassay for evaluating the chemoprevention of breast and colon cancer. Cancer Lett, 1996
  79. Inositol hexaphosphate and inositol inhibit DMBA-induced rat mammary cancer. Carcinogenesis, 1995
  80. Inositolhexakisphosphate (InsP6): an antagonist of fibroblast growth factor receptor binding and activity. In Vitro Cell Dev Biol Anim, 1994
  81. Phytase activity in the human and rat small intestine. Gut, 1994
  82. Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[alpha]anthracene. Cancer Lett, 1994
  83. [3H]inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro. J Nutr, 1994
  84. Modification of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in rats by phytic acid and its salts. Food Chem Toxicol, 1994
  85. Inhibition of rat mammary carcinogenesis by inositol hexaphosphate (phytic acid). A pilot study. Cancer Lett, 1993
  86. Two types of putative preneoplastic lesions identified by hexosaminidase activity in whole-mounts of colons from F344 rats treated with carcinogen. Am J Pathol, 1993
  87. Rodent model of renal ischemia and reperfusion injury: influence of body temperature, seasonal variation, tumor necrosis factor, endogenous and exogenous antioxidants. Methods Find Exp Clin Pharmacol, 1993
  88. Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells. J Biol Chem, 1993
  89. The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells. Biochem J, 1992
  90. Anticancer effects of phytate. Am J Clin Nutr, 1992
  91. Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate. Carcinogenesis, 1992
  92. Attempted use of zinc in vivo to protect against nitrogen mustard toxicity in tumor-free and in L1210 leukemia-bearing female B6D2F1 mice. J Appl Toxicol, 1992
  93. Antitumor activity of phytic acid (inositol hexaphosphate) in murine transplanted and metastatic fibrosarcoma, a pilot study. Cancer Lett, 1992
  94. Stimulus-induced accumulation of inositol tetrakis-, pentakis-, and hexakisphosphates in N1E-115 neuroblastoma cells. J Neurochem, 1992
  95. Carcinogenicity study in rats of phytic acid 'Daiichi', a natural food additive. Food Chem Toxicol, 1992
  96. Multiple isomers of inositol pentakisphosphate in Epstein-Barr-virus- transformed (T5-1) B-lymphocytes. Identification of inositol 1,3,4,5,6-pentakisphosphate, D-inositol 1,2,4,5,6-pentakisphosphate and L-inositol 1,2,4,5,6-pentakisphosphate. Biochem J, 1991
  97. Phytic acid and minerals: effect on early markers of risk for mammary and colon carcinogenesis. Carcinogenesis, 1991
  98. Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis, 1991
  99. Does inositol hexakisphosphate induce Ca2+ entry into GH3 cells? Biochem Soc Trans, 1991
  100. Potential radiopharmaceuticals labeled with titanium-45. Int J Rad Appl Instrum A, 1991
  101. Dose-dependent inhibition of large intestinal cancer by inositol hexaphosphate in F344 rats. Carcinogenesis, 1990
  102. Synergistic control of Ca2+ mobilization in permeabilized mouse L1210 lymphoma cells by inositol 2,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate. Biochem J, 1990
  103. The effect of iron on experimental colorectal carcinogenesis. Anticancer Res, 1989
  104. Inositol-phosphate-induced enhancement of natural killer cell activity correlates with tumor suppression. Carcinogenesis, 1989
  105. Inositol and inositol hexaphosphate suppress cell proliferation and tumor formation in CD-1 mice. Carcinogenesis, 1989
  106. Inositol hexaphosphate inhibits large intestinal cancer in F344 rats 5 months after induction by azoxymethane. Carcinogenesis, 1989
  107. Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate. Carcinogenesis, 1988
  108. Metabolism of inositol bis-, tris-, tetrakis- and pentakis-phosphates in GH3 cells. Biochem J, 1988
  109. Methylene blue protects intestinal mucosa from free radical-mediated sublethal radiation damage. Free Radic Biol Med, 1988
  110. Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR. Biochem Biophys Res Commun, 1987
  111. Inositol tetrakis- and pentakisphosphates in GH4 cells. J Exp Biol, 1985
  112. Membrane lipid composition modulates the binding specificity of a monoclonal antibody against liposomes. Biochim Biophys Acta, 1982
  113. In vitro uptake of radiocolloids by rat peritoneal macrophages and human tumor cells. Int J Nucl Med Biol, 1982
Lab studies 213
  1. Phytic Acid-Based Nanoplatform Mediates Reinforcement of Cuproptosis Induction and Pathway Inhibition. Small, 2026
  2. Targeting IP6 signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance. Nat Commun, 2026
  3. Bone-targeted calcification-photothermal nanoplatform for synergistic tumor ablation and bone regeneration in breast cancer bone metastasis. Mater Horiz, 2026
  4. Ultrasound-responsive bone-targeting liposomes suppress osteosarcoma through enhanced ROS generation and immunogenic cell death. J Control Release, 2026
  5. Phytic acid (InsP6) activates HDAC3 epigenetic axis to maintain intestinal barrier function. Nat Commun, 2026
  6. Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis. Nat Chem Biol, 2026
  7. Phytate enhances gut Parasutterella colonization to alleviate radiation injury. Cell Chem Biol, 2025
  8. Design, Synthesis, and Cellular Characterization of a New Class of IPMK Kinase Inhibitors. J Med Chem, 2025
  9. Cu-phytic acid nanozyme-induced cuproptosis therapy for the inhibition of tumor growth. Nanoscale Horiz, 2025
  10. Preparation and Anti-cancer Evaluation of Methotrexate-loaded Inositol-6 Phosphate Cross-linked Chitosan Nanoparticles on Breast Cancer. Adv Pharm Bull, 2025
  11. Evaluation of the genotoxic potential and minimisation of antinutrients in edible Xuta (Jatropha curcas L.) kernels. Food Chem Toxicol, 2025
  12. Gobal crotonylome reveals that HNRNPC and its crotonylation promote p53-deficient tumor growth by stabilizing CCND1 and MCM3 mRNAs. Cancer Lett, 2025
  13. Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate. Nat Commun, 2025
  14. A multifunctional metal-based nanozyme for CT/PTI-guided photothermal/starvation/chemodynamic therapy against colon tumor. J Mater Chem B, 2025
  15. Natural MOF-Like Photocatalytic Nanozymes Alleviate Tumor Pressure for Enhanced Nanodrug Penetration. Adv Healthc Mater, 2025
  16. Comparison of In Vitro Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from Oryza sativa L. cv. Buebang 3 CMU and Sanpatong. Plants (Basel), 2024
  17. Multi-omics approach to reveal follicular metabolic changes and their effects on oocyte competence in PCOS patients. Front Endocrinol (Lausanne), 2024
  18. Inositol Hexaphosphate (InsP6) Activates the HDAC1/3 Epigenetic Axis to Maintain Intestinal Barrier Function. bioRxiv, 2024
  19. Encapsulation of Inositol Hexakisphosphate with Chitosan via Gelation to Facilitate Cellular Delivery and Programmed Cell Death in Human Breast Cancer Cells. Bioengineering (Basel), 2024
  20. Phytic Acid Maintains Peripheral Neuron Integrity and Enhances Survivability against Platinum-Induced Degeneration via Reducing Reactive Oxygen Species and Enhancing Mitochondrial Membrane Potential. ACS Chem Neurosci, 2024
  21. Transporter targeted-carnitine modified pectin-chitosan nanoparticles for inositol hexaphosphate delivery to the colon: An in silico and in vitro approach. Int J Biol Macromol, 2024
  22. Inositol hexaphosphate enhances chemotherapy by reversing senescence induced by persistently activated PERK and diphthamide modification of eEF2. Cancer Lett, 2024
  23. Biomimetic Construction of Degradable DNAzyme-Loaded Nanocapsules for Self-Sufficient Gene Therapy of Pulmonary Metastatic Breast Cancer. ACS Nano, 2023
  24. Phytic acid-Cu2+ framework/Cu2-xS nanocomposites with heat-shock protein down-modulation ability for enhanced multimodal combination therapy. J Colloid Interface Sci, 2023
  25. The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7. Biol Pharm Bull, 2023
  26. Crosslinked and PEGylated Pectin Chitosan nanoparticles for delivery of Phytic acid to colon. Int J Pharm, 2023
  27. Highly tough and elastic microspheric gel for transarterial catheter embolization in treatment of liver metastasis tumor. Regen Biomater, 2023
  28. Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma. Drug Deliv, 2023
  29. Visualization of Food Polyphenols. J Nutr Sci Vitaminol (Tokyo), 2022
  30. Inhibitory Effect of Dietary Defatted Rice Bran in an AOM/DSS-Induced Colitis-Associated Colorectal Cancer Experimental Animal Model. Foods, 2022
  31. Phytate Hydrolysate Differently Modulates the Immune Response of Human Healthy and Cancer Colonocytes to Intestinal Bacteria. Nutrients, 2022
  32. The Anticancer Effects of Novel Imidazo[1,2-a]Pyridine Compounds against HCC1937 Breast Cancer Cells. Asian Pac J Cancer Prev, 2022
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  48. Mammary tumor inhibition by IP6: a review. Anticancer Res, 1999
  49. Protection against cancer by wheat bran: role of dietary fibre and phytochemicals. Eur J Cancer Prev, 1999
  50. Antioxidants and anticarcinogens. Eur J Cancer Prev, 1998
  51. Phytate, reactive oxygen species and colorectal cancer. Eur J Cancer Prev, 1998
  52. IP6: a novel anti-cancer agent. Life Sci, 1997
  53. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc, 1996
  54. Inositolpolyphosphates and their binding proteins--a short review. Mol Cell Biochem, 1996
  55. Phytic acid in health and disease. Crit Rev Food Sci Nutr, 1995
  56. The evidence for soybean products as cancer preventive agents. J Nutr, 1995
  57. Inositol phosphates have novel anticancer function. J Nutr, 1995
  58. Compositional changes in trypsin inhibitors, phytic acid, saponins and isoflavones related to soybean processing. J Nutr, 1995
  59. Genetic engineering of foods to reduce the risk of heart disease and cancer. Adv Exp Med Biol, 1995
  60. Antioxidants and hormone-mediated health benefits of whole grains. Crit Rev Food Sci Nutr, 1994
  61. Increasing use of soyfoods and their potential role in cancer prevention. J Am Diet Assoc, 1991
  62. Inositol phosphates in receptor-mediated cell signaling: metabolic origins and interrelationships. Biotechnol Appl Biochem, 1990
  63. Antioxidant functions of phytic acid. Free Radic Biol Med, 1990
  64. Neural function: metabolism and actions of inositol metabolites in mammalian brain. Philos Trans R Soc Lond B Biol Sci, 1988
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Other papers, not yet read by us 33
  1. Phytic Acid in Wheat Grains: A Bioactive Component With Dual Roles in Food and Health. Compr Rev Food Sci Food Saf, 2025
  2. Impact of Dietary Fiber on Inflammation in Humans. Int J Mol Sci, 2025
  3. The Relevance of Phytate for the Treatment of Chronic Kidney Disease. Clin J Am Soc Nephrol, 2024
  4. [The role of phytates in human nutrition]. Vopr Pitan, 2023
  5. [Spinach and quinoa - prospective food sources of biologically active substances]. Vopr Pitan, 2020
  6. Inositol hexaphosphate (InsP6) as an effective topical treatment for patients receiving adjuvant chemotherapy after breast surgery. Eur Rev Med Pharmacol Sci, 2017
  7. Africa's Oesophageal Cancer Corridor: Geographic Variations in Incidence Correlate with Certain Micronutrient Deficiencies. PLoS One, 2015
  8. Chemopreventive properties of dietary rice bran: current status and future prospects. Adv Nutr, 2012
  9. Whole grain intake, incident hip fracture and presumed frailty in the Iowa Women's Health Study. Br J Nutr, 2010
  10. Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical study. J Exp Clin Cancer Res, 2010
  11. Importance of functional foods in the Mediterranean diet. Public Health Nutr, 2006
  12. Mechanisms of action of novel agents for prostate cancer chemoprevention. Endocr Relat Cancer, 2006
  13. Evaluation for safety of antioxidant chemopreventive agents. Antioxid Redox Signal, 2005
  14. Prostate cancer and inositol hexaphosphate: efficacy and mechanisms. Anticancer Res, 2005
  15. Iron and zinc fortification of corn tortilla made either at the household or at industrial scale. Int J Vitam Nutr Res, 2005
  16. Zinc concentration in esophageal biopsy specimens measured by x-ray fluorescence and esophageal cancer risk. J Natl Cancer Inst, 2005
  17. Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia, 2004
  18. [Role of black bean Phaseolus vulgaris on the nutritional status of Guatemalan population]. Arch Latinoam Nutr, 2004
  19. Seeds for a better future: 'low phytate' grains help to overcome malnutrition and reduce pollution. Trends Plant Sci, 2001
  20. Dietary fiber and breast cancer. Anticancer Res, 1999
  21. Role of dietary fiber in colon cancer: an overview. Am J Med, 1999
  22. Dietary and chemopreventive strategies. Recent Results Cancer Res, 1998
  23. Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood, 1997
  24. Faecal phytic acid and its relation to other putative markers of risk for colorectal cancer. Gut, 1996
  25. Dietary fiber and the chemopreventive modelation of colon carcinogenesis. Mutat Res, 1996
  26. Association of iron with colorectal cancer. Biometals, 1994
  27. Comparison of the levels of inositol metabolites in transformed haemopoietic cells and their normal counterparts. Biochem J, 1993
  28. Suppression of colonic cancer by dietary phytic acid. Nutr Cancer, 1993
  29. Effects of inositol hexaphosphate on growth and differentiation in K-562 erythroleukemia cell line. Cancer Lett, 1992
  30. Dietary iron and colorectal cancer risk. Free Radic Biol Med, 1992
  31. Dietary suppression of colonic cancer. Fiber or phytate? Cancer, 1985
  32. Nutritional status of African populations predisposed to esophageal cancer. Nutr Cancer, 1983
  33. Zinc deficiency in human subjects. Prog Clin Biol Res, 1983

Other conditions IP6 has been studied for

Checked against PubMed on 2026-10-27. Everything we know about IP6